What principle do IACUCs generally use to evaluate potential pain in animal research procedures?

The principle used by Institutional Animal Care and Use Committees (IACUCs) to evaluate potential pain in animal research procedures focuses on the understanding that certain procedures that cause pain or distress in humans may have similar effects on animals. This reflects the belief that many animals have comparable nervous systems and sensory mechanisms that lead to the experience of pain and distress akin to those observed in humans.

By using this principle, IACUCs aim to ensure ethical treatment and minimize potential suffering of research animals, recognizing the interconnectedness of pain experiences across species. This awareness is critical for formulating guidelines and practices that not only comply with ethical standards but also advance scientific knowledge responsibly. The evaluation process encourages researchers to consider the extent of pain caused by their procedures and to seek alternative approaches that reduce harm wherever possible.