Conducting numerous, separate statistical analyses increases the chance that one or more of the results appear to be statistically significant, but are actually attributable to random variation or measurement error. This problem is referred to as:

Master Responsible Conduct of Research. Study with flashcards and multiple choice questions, each question has hints and explanations. Get ready for your exam!

The issue described in the question pertains to the concept of family-wise error rate, which is indeed referred to as family-wise inflation of error rate. When conducting multiple statistical tests, each test carries a certain probability of yielding a false positive result—where the test suggests a significant finding that does not truly exist in the population. If numerous tests are conducted independently, the overall probability of encountering at least one false positive result across all tests increases. This phenomenon is a direct result of random variation or measurement error affecting the outcomes.

In the context of responsible conduct in research, recognizing and correcting for this inflation of error rate is crucial to maintain the integrity of the research findings. Researchers employ various strategies, such as adjustments to the significance levels or employing methods like Bonferroni correction, to mitigate this risk.

Other choices do not align correctly with the problem described. Regression to the mean refers to the tendency of extreme measurements to be closer to the average upon subsequent measurements, rather than addressing the issue of false positives in multiple comparisons. Data fabrication involves intentionally creating false data, which is not the same as the statistical challenge presented. Hypothesis-free testing is a broader observational approach but does not directly address the issue of accumulated error rates across multiple tests. Hence, family

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